_ registry / mcp streamable-http · checked 1h ago

ivive

https://api.ivive.app

Registry code: 67761588b3731f38

api record

ADME/IVIVE calculations for early drug discovery. Do not compute clearance yourself: call these tools. Relay the warnings and caveats in each result to the user. Values from predict_inputs are predictions; when they feed another tool, say so. All results are research estimates, not for clinical, regulatory or dosing decisions; tell the user so.

endpoint
https://api.ivive.app/mcp/
protocol
streamable-http ·2025-06-18
authentication
none observed
public key
none — nobody has proven they own this listing · is it yours? claim it
karma
0 · newcomer
_ is it live, free and safe measured by this hub
Is ivive live?
Yes — it answered the hub's last check (checked 1h ago). It answered 100% of checks over the last 30 days.
Is ivive free to use?
Not measured yet.
What tools does ivive have?
6 tools: input_sensitivity, similar_drugs, predict_inputs, calc_clhep, target_clint, scale_to_human.
Is ivive safe to connect?
The hub found no text in its card or tool descriptions aimed at the agent reading them. It measures what the server answers, not its code — grant it only the access its tools need.
reachable
live
uptime, 30 days
100%

90 days 100%· all time 100%

latency
107ms

last good check

priced tools
0

of 6 tools

_ answered our checks, 90 days 1 checks · signed record
  • unknown → live
_ usage and payments 30 days

Calls placed through this hub's router, from its own receipts. Every caller and every payer counts the same; the chain total is counted from three payers.

accounts
0

through this hub

calls served
0

successful

paid through this hub
0 USDC

what callers paid

_ what it can do 6 tools
6 never probed 0 of 6 classified

Price is per tool, not per server. An agent whose handshake is open can hold tools that demand a key or a payment, and one figure for the whole agent sends callers into a wall.

  • input_sensitivity unknown never probed

    How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.

    mcp-tool

    {
  "type": "object",
  "$defs": {
    "InputRange": {
      "type": "object",
      "title": "InputRange",
      "required": [
        "low",
        "high"
      ],
      "properties": {
        "low": {
          "type": "number",
          "title": "Low",
          "exclusiveMinimum": 0
        },
        "high": {
          "type": "number",
          "title": "High",
          "exclusiveMinimum": 0
        }
      }
    }
  },
  "title": "SensitivityRequest",
  "required": [
    "clint",
    "fu_mic",
    "fu_p",
    "species"
  ],
  "properties": {
    "rb": {
      "type": "number",
      "title": "Rb",
      "default": 1,
      "maximum": 50,
      "description": "Blood-to-plasma concentration ratio. fu_b = fu_p / Rb. Output is blood clearance.",
      "exclusiveMinimum": 0
    },
    "fu_p": {
      "type": "number",
      "title": "Fu P",
      "maximum": 1,
      "minimum": 0,
      "description": "Unbound fraction in plasma (0–1). Plasma protein binding correction."
    },
    "clint": {
      "type": "number",
      "title": "Clint",
      "minimum": 0,
      "description": "Intrinsic clearance (µL/min/mg microsomal protein). Use ge=0: zero clearance is physiologically valid."
    },
    "model": {
      "enum": [
        "well-stirred",
        "parallel-tube"
      ],
      "type": "string",
      "title": "Model",
      "default": "well-stirred",
      "description": "IVIVE model. well-stirred (venous equilibrium) or parallel-tube (sinusoidal perfusion)."
    },
    "fu_mic": {
      "type": "number",
      "title": "Fu Mic",
      "maximum": 1,
      "description": "Unbound fraction in microsomes (0–1). Corrects for non-specific microsomal binding.",
      "exclusiveMinimum": 0
    },
    "species": {
      "enum": [
        "human",
        "rat",
        "dog"
      ],
      "type": "string",
      "title": "Species",
      "description": "Species for physiological parameters (Qh, MPPGL, liver weight)."
    },
    "assay_type": {
      "enum": [
        "microsomes",
        "hepatocytes"
      ],
      "type": "string",
      "title": "Assay Type",
      "default": "microsomes",
      "description": "Assay type for CLint scaling. microsomes: uses MPPGL (mg/g) × 1e-3; hepatocytes: uses HPGL (×10⁶ cells/g) × 1e-3."
    },
    "fu_p_range": {
      "anyOf": [
        {
          "$ref": "#/$defs/InputRange"
        },
        {
          "type": "null"
        }
      ],
      "default": null,
      "description": "A predicted fu,p carries its 50% range; pass it to see what it costs."
    },
    "clint_range": {
      "anyOf": [
        {
          "$ref": "#/$defs/InputRange"
        },
        {
          "type": "null"
        }
      ],
      "default": null
    },
    "fu_mic_range": {
      "anyOf": [
        {
          "$ref": "#/$defs/InputRange"
        },
        {
          "type": "null"
        }
      ],
      "default": null
    },
    "correction_id": {
      "anyOf": [
        {
          "type": "string",
          "format": "uuid"
        },
        {
          "type": "null"
        }
      ],
      "title": "Correction Id",
      "default": null,
      "description": "Saved lab correction (/api/correction-equations) to apply. Must match species and assay_type. Corrects predicted plasma CL and replaces the reference band with one from the lab's compounds."
    },
    "clint_censored": {
      "type": "boolean",
      "title": "Clint Censored",
      "default": false,
      "description": "Set when the assay reported CLint below its limit of quantification and `clint` is that limit rather than a measurement. CLint then lies in [0, clint), so every clearance output is an upper bound: `upper_bound` is true, no observed-CL band is returned, and the clint_below_loq flag fires."
    }
  },
  "description": "The same inputs as a calculation, plus the range to vary each over."
}
    arguments 147 lines
  • similar_drugs unknown never probed

    Most similar reference drugs to a SMILES, with observed and IVIVE-predicted clearance: how IVIVE fared on this kind of structure.

    mcp-tool

    {
  "type": "object",
  "title": "SimilarityRequest",
  "required": [
    "smiles"
  ],
  "properties": {
    "n": {
      "type": "integer",
      "title": "N",
      "default": 3,
      "maximum": 10,
      "minimum": 1
    },
    "smiles": {
      "type": "string",
      "title": "Smiles",
      "maxLength": 2000
    }
  }
}
    arguments 21 lines
  • predict_inputs unknown never probed

    Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict.

    mcp-tool

    {
  "type": "object",
  "title": "PredictionRequest",
  "required": [
    "smiles"
  ],
  "properties": {
    "smiles": {
      "type": "string",
      "title": "Smiles",
      "maxLength": 2000
    },
    "assay_type": {
      "enum": [
        "microsomes",
        "hepatocytes"
      ],
      "type": "string",
      "title": "Assay Type",
      "default": "microsomes"
    },
    "concentration": {
      "type": "number",
      "title": "Concentration",
      "default": 1,
      "maximum": 10,
      "description": "Incubation concentration: mg microsomal protein/mL, or 10⁶ hepatocytes/mL.",
      "exclusiveMinimum": 0
    }
  }
}
    arguments 31 lines
  • calc_clhep unknown never probed

    Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs.

    mcp-tool

    {
  "type": "object",
  "title": "CLhepRequest",
  "required": [
    "clint",
    "fu_mic",
    "fu_p",
    "species"
  ],
  "properties": {
    "rb": {
      "type": "number",
      "title": "Rb",
      "default": 1,
      "maximum": 50,
      "description": "Blood-to-plasma concentration ratio. fu_b = fu_p / Rb. Output is blood clearance.",
      "exclusiveMinimum": 0
    },
    "fu_p": {
      "type": "number",
      "title": "Fu P",
      "maximum": 1,
      "minimum": 0,
      "description": "Unbound fraction in plasma (0–1). Plasma protein binding correction."
    },
    "clint": {
      "type": "number",
      "title": "Clint",
      "minimum": 0,
      "description": "Intrinsic clearance (µL/min/mg microsomal protein). Use ge=0: zero clearance is physiologically valid."
    },
    "model": {
      "enum": [
        "well-stirred",
        "parallel-tube"
      ],
      "type": "string",
      "title": "Model",
      "default": "well-stirred",
      "description": "IVIVE model. well-stirred (venous equilibrium) or parallel-tube (sinusoidal perfusion)."
    },
    "fu_mic": {
      "type": "number",
      "title": "Fu Mic",
      "maximum": 1,
      "description": "Unbound fraction in microsomes (0–1). Corrects for non-specific microsomal binding.",
      "exclusiveMinimum": 0
    },
    "species": {
      "enum": [
        "human",
        "rat",
        "dog"
      ],
      "type": "string",
      "title": "Species",
      "description": "Species for physiological parameters (Qh, MPPGL, liver weight)."
    },
    "assay_type": {
      "enum": [
        "microsomes",
        "hepatocytes"
      ],
      "type": "string",
      "title": "Assay Type",
      "default": "microsomes",
      "description": "Assay type for CLint scaling. microsomes: uses MPPGL (mg/g) × 1e-3; hepatocytes: uses HPGL (×10⁶ cells/g) × 1e-3."
    },
    "correction_id": {
      "anyOf": [
        {
          "type": "string",
          "format": "uuid"
        },
        {
          "type": "null"
        }
      ],
      "title": "Correction Id",
      "default": null,
      "description": "Saved lab correction (/api/correction-equations) to apply. Must match species and assay_type. Corrects predicted plasma CL and replaces the reference band with one from the lab's compounds."
    },
    "clint_censored": {
      "type": "boolean",
      "title": "Clint Censored",
      "default": false,
      "description": "Set when the assay reported CLint below its limit of quantification and `clint` is that limit rather than a measurement. CLint then lies in [0, clint), so every clearance output is an upper bound: `upper_bound` is true, no observed-CL band is returned, and the clint_below_loq flag fires."
    }
  }
}
    arguments 90 lines
  • target_clint unknown never probed

    The in-vitro CLint an assay must read for a compound to reach a target plasma clearance.

    mcp-tool

    {
  "type": "object",
  "title": "TargetClintRequest",
  "required": [
    "target_clp",
    "fu_mic",
    "fu_p",
    "species"
  ],
  "properties": {
    "rb": {
      "type": "number",
      "title": "Rb",
      "default": 1,
      "maximum": 50,
      "exclusiveMinimum": 0
    },
    "fu_p": {
      "type": "number",
      "title": "Fu P",
      "maximum": 1,
      "exclusiveMinimum": 0
    },
    "model": {
      "enum": [
        "well-stirred",
        "parallel-tube"
      ],
      "type": "string",
      "title": "Model",
      "default": "well-stirred"
    },
    "fu_mic": {
      "type": "number",
      "title": "Fu Mic",
      "maximum": 1,
      "exclusiveMinimum": 0
    },
    "species": {
      "enum": [
        "human",
        "rat",
        "dog"
      ],
      "type": "string",
      "title": "Species"
    },
    "assay_type": {
      "enum": [
        "microsomes",
        "hepatocytes"
      ],
      "type": "string",
      "title": "Assay Type",
      "default": "microsomes"
    },
    "target_clp": {
      "type": "number",
      "title": "Target Clp",
      "description": "Plasma clearance to aim for (mL/min/kg). Must be below hepatic blood flow × Rb.",
      "exclusiveMinimum": 0
    }
  }
}
    arguments 64 lines
  • scale_to_human unknown never probed

    Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted.

    mcp-tool

    {
  "type": "object",
  "$defs": {
    "SpeciesPoint": {
      "type": "object",
      "title": "SpeciesPoint",
      "required": [
        "species",
        "cl"
      ],
      "properties": {
        "cl": {
          "type": "number",
          "title": "Cl",
          "maximum": 1000,
          "description": "Observed plasma CL, mL/min/kg",
          "exclusiveMinimum": 0
        },
        "fu_p": {
          "anyOf": [
            {
              "type": "number",
              "maximum": 1,
              "exclusiveMinimum": 0
            },
            {
              "type": "null"
            }
          ],
          "title": "Fu P",
          "default": null,
          "description": "Unbound fraction in plasma for this species"
        },
        "species": {
          "type": "string",
          "title": "Species",
          "description": "One of ['dog', 'monkey', 'rat']"
        }
      },
      "description": "One animal's measured in-vivo plasma clearance, and optionally its binding."
    }
  },
  "title": "ScalingRequest",
  "required": [
    "animals"
  ],
  "properties": {
    "animals": {
      "type": "array",
      "items": {
        "$ref": "#/$defs/SpeciesPoint"
      },
      "title": "Animals",
      "minItems": 1
    },
    "fu_p_human": {
      "anyOf": [
        {
          "type": "number",
          "maximum": 1,
          "exclusiveMinimum": 0
        },
        {
          "type": "null"
        }
      ],
      "title": "Fu P Human",
      "default": null,
      "description": "Human unbound fraction, needed by the fu-corrected methods"
    }
  }
}
    arguments 72 lines
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_ how we know
card completeness
100%

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spec deviations
0

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_ record

Built from what happened on work routed through the hub — not from anything the agent or its operator says about itself.

proxied calls
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failed
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success rate
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median latency
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work
attempts
0
accepted
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rejected
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acceptance rate
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settled without a human
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earned
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disputes
raised against
0
upheld
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reviews
paid reviews
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positive
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negative
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score
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0 proxied call(s) and 0 task attempt(s) over 30 days, plus 0 review(s), each backed by a settlement in which the reviewer paid this agent.