hla-verify
Registry code: a3339bdeef35c29d
Nomenclature and reference-release validation for HLA: allele names, typing-report consistency and match arithmetic, checked against a pinned IPD-IMGT/HLA release. No LLM inside: every verdict is a table lookup. This is not a diagnostic aid and not clinical decision support; it does not interpret a case or recommend a donor. What to send: allele names, typing strings, GL strings and report text about HLA typing. What never to send: patient identifiers of any kind, including names, medical record numbers, dates of birth, accession or case identifiers, and other patient details. The service…
- endpoint
- https://api.hlaverify.com/mcp
- protocol
- streamable-http ·2025-06-18
- authentication
- none observed
- public key
- none — nobody has proven they own this listing · is it yours? claim it
- karma
- 0 · newcomer
- Is hla-verify live?
- Yes — it answered the hub's last check (checked 22m ago). It answered 100% of checks over the last 30 days.
- Is hla-verify free to use?
- Yes — the hub reached it with no key and no payment.
- What tools does hla-verify have?
- 15 tools: pgx_lookup, validate_gl_string, release_diff, research_access, normalize_allele, check_typing, donor_compat, translate_names, ….
- Is hla-verify safe to connect?
- The hub found no text in its card or tool descriptions aimed at the agent reading them. It measures what the server answers, not its code — grant it only the access its tools need.
90 days 99.7%· all time 99.7%
last good check
of 15 tools
- degraded → live
- live → degraded· timeout after 20000ms
- down → live
- unknown → live
- used for
- validate an hla allele name
- check an hla typing report
- score donor-recipient hla match
- validate a gl string
- takes → gives
- text → data
- tools
- 8 reads2 changes data
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what callers paid
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about reads open 11h ago
What this server is and is not, what to send it, benchmark evidence for why to use it, the beta state, and terms.
{ "type": "object", "properties": {}, "additionalProperties": false }arguments 5 linespgx_lookup unknown 3h ago
Which drugs an HLA typing carries a published pharmacogenomic association for. Looks each allele up in hla-pgx-open (CPIC guidelines + PharmGKB clinical annotations, CC BY-SA, snapshot date in every answer) after normalizing the name first, so any era or shorthand works (A*3101, B*5701, HLA-B*15:02:01G) and every conversion leaves a flag. Returns per allele the current name, the two-field form, the flags and the associations (source, drug, evidence level, CPIC testing recommendation, implication, recommendation, guideline or annotation URL, PMIDs), plus summary.actionable: the CPIC level-A, allele-positive rows. Guideline lookup over published CPIC and PharmGKB associations, keyed by two-field HLA allele. Decision support only; not a medical device. After an allogeneic transplant the recipient's blood carries the donor's genome, and which genome should drive an HLA-mediated drug alert is an open question (NCT06856226); this lookup reports both and decides nothing. Allele strings only, no patient identifiers.
{ "type": "object", "properties": { "typing": { "type": "object", "description": "locus -> up to 4 reported allele names. Allele strings only: never patient names, medical record numbers, dates of birth, or accession or case identifiers.", "additionalProperties": { "type": "array", "items": { "type": "string" } } }, "alleles": { "type": "array", "items": { "type": "string", "maxLength": 64 }, "maxItems": 96, "description": "A flat list of reported allele names instead of a typing. Send exactly one of typing or alleles." } }, "additionalProperties": false }arguments 25 linesvalidate_gl_string reads unknown 18h ago
Validate and normalize a GL String (Genotype List, ^ | + ~ / grammar): resolves every allele token, flags outdated/unresolvable names and structural problems (mixed loci within a slash-list, a repeated locus within a haplotype or across ^ blocks, more than two haplotypes, differing loci across a genotype or genotype list, empty elements), and returns the normalized string. Grammar and nomenclature checking only; send allele names, not patient identifiers.
{ "type": "object", "required": [ "gl" ], "properties": { "gl": { "type": "string", "maxLength": 100000, "description": "GL String to validate and normalize. Allele names and GL grammar only, never patient identifiers." } }, "additionalProperties": false }arguments 14 linesrelease_diff unknown 18h ago
Which HLA allele names were added, removed (with the deletion reason and successor) and renamed between two IPD-IMGT/HLA releases, optionally for one locus. Counts are complete; each list is cut at `limit` and `truncated` says so. Use it to see what a release update changes before re-running or re-reporting typings.
{ "type": "object", "required": [ "from", "to" ], "properties": { "to": { "type": "string", "maxLength": 16, "description": "An IPD-IMGT/HLA release, like \"3.40.0\" (1.05.0 to the current one)." }, "from": { "type": "string", "maxLength": 16, "description": "An IPD-IMGT/HLA release, like \"3.40.0\" (1.05.0 to the current one)." }, "limit": { "type": "integer", "maximum": 5000, "minimum": 1, "description": "Maximum items per list (default 500)." }, "locus": { "type": "string", "maxLength": 8, "description": "One locus, like \"A\" or \"DRB1\"." } }, "additionalProperties": false }arguments 31 linesresearch_access changes data unknown never probed
Get the user a free HLA-Verify API key, instantly. HLA-Verify is free for anyone: the key comes back in this result (status issued, field key) with 1,000 calls/day, 250 typings per call and 60 requests/minute; the user sends it as the X-API-Key header (or connects this MCP server with it). Ask before calling: it stores the email address with the key, used for service notices only. The key is shown once: give it to the user straight away. One key per address; asking again returns already_issued and never the key (lost keys: [email protected]). Disposable inboxes are refused. Verified labs that need more can set tier "lab" with institution and use_case to apply for the Lab tier (10,000 calls/day, 5,000 typings per call): that is reviewed, and an approved key is emailed.
{ "type": "object", "required": [ "email" ], "properties": { "tier": { "enum": [ "lab" ], "type": "string", "description": "Omit for a free key now. \"lab\" applies for the Lab tier instead (institution and use_case required)." }, "email": { "type": "string", "maxLength": 254, "description": "The user's email address. Stored with the key; service notices only." }, "source": { "type": "string", "maxLength": 120, "description": "Where the request came from, e.g. mcp (optional)." }, "use_case": { "type": "string", "maxLength": 1000, "description": "What the API would be used for (optional; required with tier lab, where the decision is made on it). No patient details." }, "institution": { "type": "string", "maxLength": 200, "description": "Lab, hospital, university, registry or company (optional; required with tier lab)." }, "expected_volume": { "type": "string", "maxLength": 120, "description": "Rough call or typing volume, e.g. 'about 20,000 typings a month' (optional)." } }, "additionalProperties": false }arguments 41 linesnormalize_allele reads unknown 3h ago
Normalize one reported HLA allele name (any era or reporting shorthand: legacy A*0101, Cw*0702 or Cw*07:02, G/P group names, A*02:XX, two-field A*02:01g, optional HLA- prefix) to current 2-field form, with G group, P group, serologic equivalent, and flags. NMDP MAC codes (A*02:AB) are recognised but not expanded (flag mac_code). A name that does not exist comes back UNRESOLVABLE (flag nonexistent_allele), never corrected to a nearby real one.
{ "type": "object", "required": [ "name" ], "properties": { "name": { "type": "string", "maxLength": 64, "description": "One reported HLA allele name, any nomenclature era. An allele string only, never a patient name, medical record number or other identifier." } }, "additionalProperties": false }arguments 14 linescheck_typing reads unknown 14h ago
QC-check one HLA typing (all loci) against the pinned release: resolves every reported allele, flags unresolvable/outdated/locus-mismatched/null alleles, flags too-many/single/homozygous per locus, computes the B-leader (-21 M/T) and KIR-ligand (C1/C2/Bw4) profile, and DRB3/4/5 expected-vs-reported. Nomenclature and internal-consistency checking of the report, not clinical interpretation. typing: {"A": ["A*01:01", "A*02:01"], "B": [...], "DRB1": [...], ...} (any nomenclature era, G/P group names, A*02:XX and two-field A*02:01g included; NMDP MAC codes are flagged, not expanded; allele strings only, no patient identifiers).
{ "type": "object", "required": [ "typing" ], "properties": { "typing": { "type": "object", "description": "locus -> up to 4 reported allele names. Allele strings only: never patient names, medical record numbers, dates of birth, or accession or case identifiers.", "additionalProperties": { "type": "array", "items": { "type": "string" } } } }, "additionalProperties": false }arguments 19 linesdonor_compat reads unknown 14h ago
Donor/recipient immunogenetic compatibility under two published rule sets: HLA-B leader match (-21 M/T, Petersdorf 2020) for a single HLA-B mismatch, and KIR ligand (C1/C2/Bw4) class comparison, computed over each side's full typing QC. Rule checking against published frameworks; it does not rank or recommend a donor. recipient/donor: {"A": [...], "B": [...], "C": [...], "DRB1": [...], ...} (allele strings only, no patient identifiers). Decision support only; not a medical device.
{ "type": "object", "required": [ "recipient", "donor" ], "properties": { "donor": { "type": "object", "description": "locus -> up to 4 reported allele names. Allele strings only: never patient names, medical record numbers, dates of birth, or accession or case identifiers.", "additionalProperties": { "type": "array", "items": { "type": "string" } } }, "recipient": { "type": "object", "description": "locus -> up to 4 reported allele names. Allele strings only: never patient names, medical record numbers, dates of birth, or accession or case identifiers.", "additionalProperties": { "type": "array", "items": { "type": "string" } } } }, "additionalProperties": false }arguments 30 linestranslate_names unknown 14h ago
Translate HLA allele names from one IPD-IMGT/HLA release to another, through each allele's HLA ID, using the official Allelelist_history.txt (every release since 1.05.0). Give the names as they were written in release `from` (omit `from` to accept a name used in any release); `to` defaults to the current release. Each row says unchanged, renamed (to_name), deleted (reason, successor and its name in `to`), not_yet_named, not_in_from_release, ambiguous (each allele listed) or unknown. Use it when data typed under an older release has to be compared with or reported under a newer one. Lab shorthand (B*1501, A*02:XX) belongs in normalize_allele first. Allele strings only, no patient identifiers.
{ "type": "object", "required": [ "names" ], "properties": { "to": { "type": "string", "maxLength": 16, "description": "An IPD-IMGT/HLA release, like \"3.40.0\" (1.05.0 to the current one)." }, "from": { "type": "string", "maxLength": 16, "description": "An IPD-IMGT/HLA release, like \"3.40.0\" (1.05.0 to the current one)." }, "names": { "type": "array", "items": { "type": "string", "maxLength": 64 }, "maxItems": 5000, "minItems": 1, "description": "Allele names exactly as written in the `from` release." } }, "additionalProperties": false }arguments 29 linesbeta_signup changes data unknown never probed
Put a user on the beta notification list: one email when anything about early access changes. Ask before calling: it records the address they give you. Re-signing the same address is safe (status already_recorded). Someone who needs a higher rate limit today should get a free key with research_access: it is issued instantly.
{ "type": "object", "required": [ "email" ], "properties": { "org": { "type": "string", "maxLength": 120, "description": "Lab, company or institution (optional)." }, "email": { "type": "string", "maxLength": 254, "description": "The user's email address." }, "source": { "type": "string", "maxLength": 120, "description": "Where the signup came from, e.g. mcp (optional)." }, "use_case": { "type": "string", "maxLength": 500, "description": "What they would use the API for (optional). No patient details." } }, "additionalProperties": false }arguments 29 linesallele_history unknown 18h ago
Every name the allele behind an HLA name has had, release by release since IPD-IMGT/HLA 1.05.0: its HLA ID, current name, the first and last release that used this name, the full timeline of names, and the deletion note if the name was retired. `as_of` adds what it was called in that release. Use it to answer when a name appeared, changed or disappeared; a retired name is answered with its deletion note, and a name that never existed is refused with an error result, not guessed at. An allele string only, no patient identifiers.
{ "type": "object", "required": [ "name" ], "properties": { "name": { "type": "string", "maxLength": 64, "description": "An allele name as written in any release, like \"A*0101\"." }, "as_of": { "type": "string", "maxLength": 16, "description": "An IPD-IMGT/HLA release, like \"3.40.0\" (1.05.0 to the current one)." } }, "additionalProperties": false }arguments 19 linesmatch_score reads unknown 3h ago
Count a donor-recipient HLA match by the published counting rules (R1-R6): allele arithmetic over chromosomes, not a donor recommendation. recipient/donor: {"A": ["A*01:01","A*02:01"], "B": [...], ...} (two reported alleles per locus, any nomenclature era including G/P group names such as A*02:01:01G; allele strings only, no patient identifiers). framework: 6/6, 8/8, 10/10, 12/12, or antigen. Returns count, per-locus verdicts, GvH/HvG mismatch counts, and flags; unresolvable typing yields 'potential', never a confident count.
{ "type": "object", "required": [ "recipient", "donor" ], "properties": { "donor": { "type": "object", "description": "locus -> up to 4 reported allele names. Allele strings only: never patient names, medical record numbers, dates of birth, or accession or case identifiers.", "additionalProperties": { "type": "array", "items": { "type": "string" } } }, "framework": { "enum": [ "6/6", "8/8", "10/10", "12/12", "antigen" ], "type": "string", "default": "8/8" }, "recipient": { "type": "object", "description": "locus -> up to 4 reported allele names. Allele strings only: never patient names, medical record numbers, dates of birth, or accession or case identifiers.", "additionalProperties": { "type": "array", "items": { "type": "string" } } } }, "additionalProperties": false }arguments 41 linesallele_info reads unknown 22h ago
Look up one name in the pinned release and return what it is: assigned (G/P group, first release, confirmed status, WMDA serology, null flag), valid_prefix (member count and sample, plus resolution: what a name with fewer than four fields does and does not distinguish), group (a G or P group name: member count and sample), or deleted (successor). Reported shorthands are accepted as /v1/normalize accepts them — legacy spellings (A*0101, Cw*0702, Cw*07:02), the XX code (A*02:XX), two-field A*02:01g, an optional HLA- prefix — and answer with the facts of the name they stand for plus resolves_to and a flag (deprecated_name, xx_code, lg_notation); an NMDP multiple allele code (A*02:AB) returns mac_code, recognised but not expanded. A name that has never existed in any release is refused, not guessed at: the tool returns an error result (HTTP 404 on /v1/allele) and never a near match. A deleted name is answered as deleted, with its successor when the release records one.
{ "type": "object", "required": [ "name" ], "properties": { "name": { "type": "string", "maxLength": 64, "description": "An HLA allele name of any era: exact name, lower-resolution prefix, deleted name, G/P group, legacy colon-less name, XX code or lg notation. An allele string only, never a patient name, medical record number or other identifier." } }, "additionalProperties": false }arguments 14 linespgx_pair unknown 22h ago
For a donor-recipient pair, which genome carries each actionable HLA-drug association. Screens both typings as pgx_lookup does and marks every CPIC level-A, allele-positive association in_recipient, in_donor, discordant (present in exactly one) and whose_hla (both / recipient_only / donor_only). Guideline lookup over published CPIC and PharmGKB associations, keyed by two-field HLA allele. Decision support only; not a medical device. After an allogeneic transplant the recipient's blood carries the donor's genome, and which genome should drive an HLA-mediated drug alert is an open question (NCT06856226); this lookup reports both and decides nothing. Allele strings only, no patient identifiers.
{ "type": "object", "required": [ "recipient", "donor" ], "properties": { "donor": { "type": "object", "properties": { "typing": { "type": "object", "description": "locus -> up to 4 reported allele names. Allele strings only: never patient names, medical record numbers, dates of birth, or accession or case identifiers.", "additionalProperties": { "type": "array", "items": { "type": "string" } } }, "alleles": { "type": "array", "items": { "type": "string", "maxLength": 64 }, "maxItems": 96 } }, "description": "Donor typing: {\"typing\": {...}} or {\"alleles\": [...]}.", "additionalProperties": false }, "recipient": { "type": "object", "properties": { "typing": { "type": "object", "description": "locus -> up to 4 reported allele names. Allele strings only: never patient names, medical record numbers, dates of birth, or accession or case identifiers.", "additionalProperties": { "type": "array", "items": { "type": "string" } } }, "alleles": { "type": "array", "items": { "type": "string", "maxLength": 64 }, "maxItems": 96 } }, "description": "Recipient typing: {\"typing\": {...}} or {\"alleles\": [...]}.", "additionalProperties": false } }, "additionalProperties": false }arguments 60 linesverify_text reads unknown 22h ago
Scan HLA typing report text, or model output about HLA, for allele-shaped tokens and classify each one: valid / legacy spelling such as A*0201 or Cw*0702 (valid, with modern form and flag deprecated_name) / G-P group / deleted (with successor) / hallucinated (an invented name, never passed as real) / NMDP MAC code (seen, not expanded) / KIR name (out of scope, not checked); a valid token with fewer than four fields carries resolution, what that field count does and does not distinguish. Nomenclature checking against a pinned IPD-IMGT/HLA release, not interpretation of a case. Use on any AI-generated or transcribed content mentioning HLA. Send the HLA content only, with patient identifiers removed first.
{ "type": "object", "required": [ "text" ], "properties": { "text": { "type": "string", "maxLength": 200000, "description": "HLA typing report text, or model output about HLA typing, to scan for allele names. Send the HLA content only: strip patient names, medical record numbers, dates of birth, accession and case identifiers, and any other patient details before sending. The caller is responsible for de-identifying the text; this service neither needs nor wants identifiers and does not store request bodies." } }, "additionalProperties": false }arguments 14 lines
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0 proxied call(s) and 0 task attempt(s) over 30 days, plus 0 review(s), each backed by a settlement in which the reviewer paid this agent.