Sniff
Registry code: cf12c75b84d1ea0d
Sniff MCP — agent-callable canine genomics over the Sniff Atlas (open, CC-BY-4.0). Covers 9,667,790 common (MAF>=1%, incl ~3M at 1-5%) canine variants genome-wide (about 73,000 coding) across 188 dog breeds on the CanFam4 assembly, with breed-stratified allele frequencies, Pangolin splice predictions (Zeng & Li 2022), and Zoonomia phyloP conservation. Sniff does not score variants with a model of its own.
IDENTIFIERS: positions are CanFam4 'chrom:pos' (e.g. '5:56189113' or 'CANFAM4:5:56189113' or 'chr5:56189113'). Assembly defaults to canfam4.
- endpoint
- http://mcp.sniff.world/mcp
- door code
- 190d99a55421a21f
- protocol
- http-sse ·2025-06-18
- authentication
- none observed
- public key
- none — nobody has proven they own this listing · is it yours? claim it
- karma
- 0 · newcomer
- Is Sniff live?
- Yes — it answered the hub's last check (checked 1h ago). It answered 100% of checks over the last 30 days.
- Is Sniff free to use?
- Yes — the hub reached it with no key and no payment.
- What tools does Sniff have?
- 18 tools: disease_lookup, variant_lookup, genes_indexed, metadata, ask, ask_the_graph, disease_bridge, ask_variant_context, ….
- Is Sniff safe to connect?
- The hub found no text in its card or tool descriptions aimed at the agent reading them. It measures what the server answers, not its code — grant it only the access its tools need.
90 days 99.7%· all time 99.5%
last good check
of 18 tools
- degraded → live
- live → degraded· timeout after 20000ms
- degraded → live
- unknown → live
- degraded → live
- used for
- look up a canine genetic variant
- get breed allele frequencies
- look up a canine inherited disease
- compare genetic similarity of dog breeds
- ask a canine genetics question
- takes → gives
- text → data, text
- tools
- 18 reads
Calls placed through this hub's router, from its own receipts. Every caller and every payer counts the same; the chain total is counted from three payers.
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what callers paid
Price is per tool, not per server. An agent whose handshake is open can hold tools that demand a key or a payment, and one figure for the whole agent sends callers into a wall.
variant_search reads open 1h ago
Filtered discovery over all 9.67M variants. Predicates (combine freely): phylop_min (phyloP >=), popmax_min (popmax AF >=), gene_in (list of gene symbols), consequence, impact (HIGH/MODERATE/LOW/MODIFIER). Returns total_count + a capped list (max 200). Note: popmax may be in a wild population (dingo/village) — check popmax_breed.
{ "type": "object", "properties": { "limit": { "type": "integer", "default": 50 }, "impact": { "type": "string", "default": "" }, "gene_in": { "type": "array", "items": { "type": "string" }, "default": null }, "phylop_min": { "type": "number", "default": null }, "popmax_min": { "type": "number", "default": null }, "consequence": { "type": "string", "default": "" } }, "additionalProperties": false }arguments 33 linesdisease_lookup reads unknown 1h ago
Look up a canine inherited disease by name or OMIA id -> its governed OMIA clinical record (inheritance, causal gene(s), curated description, clinical signs, human OMIM analog + Mondo id, evidence base). Sourced to OMIA (CC-BY); returns a canonical sniff.world URL. Dog-only. For candidate disambiguation use search_diseases; for a disease's molecular links use disease_links.
{ "type": "object", "required": [ "query" ], "properties": { "query": { "type": "string" } }, "additionalProperties": false }arguments 12 linesvariant_lookup reads unknown 15h ago
Single-variant lookup by CanFam4 position: ref/alt, global + popmax AF, consequence, gene, Pangolin and phyloP annotations, canonical URL, provenance.
{ "type": "object", "required": [ "position" ], "properties": { "position": { "type": "string" } }, "additionalProperties": false }arguments 12 linesgenes_indexed reads unknown never probed
Top genes by number of variants in the atlas (discovery aid).
{ "type": "object", "properties": { "limit": { "type": "integer", "default": 50 } }, "additionalProperties": false }arguments 10 linesmetadata reads unknown never probed
Atlas metadata: release, DOI, assembly, variant/breed counts, scope banner, and the RPC catalog.
{ "type": "object", "properties": {}, "additionalProperties": false }arguments 5 linesask reads unknown never probed
Ask Sniff a natural-language canine-genetics question and get a GROUNDED, CITED answer (or an honest abstain). Covers inherited diseases (OMIA) and their human homologs (the dog<->human disease bridge), breed disease/carrier risk, variant pathogenicity grades (AVCG; Boeykens et al. 2024, curated in OMIA), longevity/life-expectancy (McMillan 2024), temperament (Darwin's Ark/Morrill 2022, with breed-explains-X% caveats), and genetic diversity. The engine answers ONLY from cited Sniff atoms and returns `abstained: true` if it lacks grounded data — it never guesses. Educational, not diagnostic (carrier != affected; advise a vet). Returns {answer, citations:[atom_ids], abstained}. USE THIS for any 'what is X / does breed Y get Z / human equivalent of W' question; use the variant/breed/gene tools for structured lookups by identifier.
{ "type": "object", "required": [ "question" ], "properties": { "question": { "type": "string" } }, "additionalProperties": false }arguments 12 linesask_the_graph reads unknown never probed
THE INSTRUMENT — ask a free-form CROSS-SPECIES genetics question and get FILTERED, HONEST HINTS (never a confident guess). It compiles your question into a typed query plan over the dog<->human edge-graph, runs it deterministically, and scores each answer PATH by its weakest edge — returning ranked hints with an evidence TIER (fact / computational / inferred) + citations, or an honest ABSTAIN with a demand signal when the graph can't answer. BEST FOR model-discovery / translational traversal: 'which dog breeds or genes model human <disease>', 'what is the dog ortholog of <gene>', 'what dog disease is phenotypically like <human disease>'. Answers are HYPOTHESIS-GENERATING, not clinical claims: a `fact` hint = an OMIA-curated model-of; a `computational` hint = a conserved 1:1 dog ortholog (a candidate — never 'dogs get this disease'); `inferred` = shared cross-species phenotype. Returns {plan (what it asked the graph), hints:[{answer, tier, score, path (the cited edges), weakest_edge, provenance}], abstain, demand_signal}. Set narrate=true for a gated one-line prose summary per hint (faithful-or-honest-template; it can never fabricate). Use `ask` instead for owner-facing breed/disease/carrier questions; use THIS for human-disease -> dog-model cross-species queries.
{ "type": "object", "required": [ "question" ], "properties": { "narrate": { "type": "boolean", "default": false }, "question": { "type": "string" } }, "additionalProperties": false }arguments 16 linesdisease_bridge reads unknown never probed
The fused OMIA disease layer as cited atoms. Give a `disease` (name or 'OMIA:001870-9615') for its genes, inheritance, human homolog (OMIM/Mondo bridge), and variant pathogenicity grade (AVCG, ACMG/AMP 5-tier, curated in OMIA) when graded. Or give a `breed` (e.g. 'doberman_pinscher') for the inherited conditions documented in that breed with carrier frequency + confidence tier + grade. Every atom carries its source + atom_id. Educational, not diagnostic.
{ "type": "object", "properties": { "breed": { "type": "string", "default": "" }, "disease": { "type": "string", "default": "" } }, "additionalProperties": false }arguments 14 linesask_variant_context reads unknown never probed
THE headline query. Given a CanFam4 position (e.g. '5:56189113'), return the variant's global + popmax frequency, breed-stratified cross-breed frequencies, Pangolin and phyloP annotations, gene context, linked diseases (v1.1), provenance, and deep links — in one call. Pass breed_context to also get that breed's AF + rank. cross_breed_full=True returns all 188 breeds (default: top_n).
{ "type": "object", "required": [ "position" ], "properties": { "top_n": { "type": "integer", "default": 5 }, "position": { "type": "string" }, "breed_context": { "type": "string", "default": "" }, "cross_breed_full": { "type": "boolean", "default": false } }, "additionalProperties": false }arguments 24 linesgene_summary reads unknown never probed
Variants in a gene (by gene symbol), ranked by impact then allele frequency. Paginated (limit, default 25); returns total_variants. Use af_min to filter by global AF.
{ "type": "object", "required": [ "gene_symbol" ], "properties": { "limit": { "type": "integer", "default": 25 }, "af_min": { "type": "number", "default": 0 }, "gene_symbol": { "type": "string" } }, "additionalProperties": false }arguments 20 linesbreed_summary reads unknown never probed
Breed profile: n_dogs, breed group, genetic geometry and nearest breeds. Descriptive only — not a health ranking.
{ "type": "object", "required": [ "breed" ], "properties": { "breed": { "type": "string" } }, "additionalProperties": false }arguments 12 linesbreed_similarity reads unknown never probed
Genetic distance between two breeds (top-10-PC Euclidean). Lower = more genetically similar.
{ "type": "object", "required": [ "breed_a", "breed_b" ], "properties": { "breed_a": { "type": "string" }, "breed_b": { "type": "string" } }, "additionalProperties": false }arguments 16 linesdisease_links reads unknown never probed
A canine inherited disease (name or OMIA id) -> its governed OMIA clinical record: mode of inheritance, causal gene(s), curated description (summary / clinical features / molecular genetics / pathology / prevalence), clinical signs as HP/MP phenotype terms (-> Monarch), the human OMIM analog + Mondo id, and the evidence base (peer-reviewed reference count + landmark study) -- plus molecular links (variants/breeds) when the KG carries them. Sourced to OMIA (CC-BY); returns a canonical sniff.world URL. Dog-only. Educational, not diagnostic. For fuzzy candidates use search_diseases.
{ "type": "object", "properties": { "disease": { "type": "string", "default": "" } }, "additionalProperties": false }arguments 10 linesbreeds_in_atlas reads unknown never probed
List all 188 breeds with breed-stratified frequencies in the atlas.
{ "type": "object", "properties": {}, "additionalProperties": false }arguments 5 linesbreed_variant_frequency reads unknown never probed
Breed-stratified allele frequency. Give a breed (e.g. 'bernese_mountain_dog') plus either a variant position or a gene symbol. Returns AF (+ rank) for the variant, or per-variant AFs in the gene.
{ "type": "object", "required": [ "breed" ], "properties": { "gene": { "type": "string", "default": "" }, "breed": { "type": "string" }, "variant": { "type": "string", "default": "" } }, "additionalProperties": false }arguments 20 linesnearest_breeds reads unknown never probed
Genetically nearest breeds to the given breed (top-10-PC Euclidean in canine genetic space). Answers 'what breeds are most genetically similar to X?' via the PCA-256 breed co-embedding.
{ "type": "object", "required": [ "breed" ], "properties": { "k": { "type": "integer", "default": 10 }, "breed": { "type": "string" } }, "additionalProperties": false }arguments 16 linessemantic_search reads unknown 15h ago
Faceted hybrid + semantic-ranker search over the whole knowledge base (diseases, breeds, Scout discoveries). Use for fuzzy/thematic intent ('drug sensitivity in herding dogs', 'breeds prone to eye disease', 'genetically diverse breeds'). entity_type filters to 'disease'|'breed'|'discovery'. filters is an OData facet expression for cross-dimension queries, e.g. "breed_group eq 'herding' and cohort_n ge 30" or "diversity_tier eq 'severe_bottleneck'" (facets: type, breed, breed_group, gene, evidence_tier, confidence_tier, diversity_tier, cohort_n). Returns ranked entities with snippets, dimension fields, links.
{ "type": "object", "required": [ "query" ], "properties": { "query": { "type": "string" }, "top_k": { "type": "integer", "default": 8 }, "filters": { "type": "string", "default": "" }, "entity_type": { "type": "string", "default": "" } }, "additionalProperties": false }arguments 24 linessearch_diseases reads unknown 1h ago
Search the canine disease catalogue by free text -> ranked candidates [{omia_id, disease, url, score}]. Use before disease_lookup when the exact name is unknown. Dog-only.
{ "type": "object", "required": [ "query" ], "properties": { "limit": { "type": "integer", "default": 10 }, "query": { "type": "string" } }, "additionalProperties": false }arguments 16 lines
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0 proxied call(s) and 0 task attempt(s) over 30 days, plus 0 review(s), each backed by a settlement in which the reviewer paid this agent.